DEFINITE HIGH RISK (INCLUDING ASYMPTOMATIC CMT)

• Vinca alkaloids (Vincristine)
• Taxols (paclitaxel, docetaxel, cabazitaxel)

MODERATE TO SIGNIFICANT RISK

• Amiodarone (Cordarone)
• Arsenic Trioxide (Trisenox)
• Bortezomib (Velcade)
• Brentuximab Vedotin(Adcetris)
• Cetuximab (Erbitux)
• Cisplatin & Oxaliplatin
• Colchicine (extended use)
• Dapsone
• Didanosine (ddI, Videx)
• Dichloroacetate
• Disulfiram (Antabuse)
• Eribulin (Halaven)
• Fluoroquinolones
• Gold salts
• Ipilimumab (Yervoy)
• Ixabepilone (Ixempra)
• Leflunomide (Arava)
• Lenalidomide (Revlimid)
• Metronidazole/Misonidazole (extended use)
• Nitrofurantoin (Macrodantin, Furadantin, Macrobid)
• Nitrous oxide (inhalation abuse or Vitamin B12 deficiency)
• Nivolumab (Opdivo)
• Pembrolizumab (Keytruda)
• Perhexiline (not used in U.S.)
• Pomalidomide (Pomalyst)
• Pyridoxine (Although megadoses [10 times or more the RDA] of Vitamin B6 may be harmful, high intakes of vitamin B6 from food sources have not been reported to cause adverse effects.) NIH Fact Sheet
• Stavudine (d4T, Zerit)
• Suramin
• Thalidomide
• Zalcitabine (ddC, Hivid)

This is a list of the most common neurotoxic drugs for CMT, however, it may not include every drug with neurotoxic effects. Please talk with your doctor before starting or changing a medication.