DEFINITE HIGH RISK (INCLUDING ASYMPTOMATIC CMT)
- Vinca alkaloids (Vincristine)
- Taxols (paclitaxel, docetaxel, cabazitaxel)
MODERATE TO SIGNIFICANT RISK
- Amiodarone (Cordarone)
- Arsenic Trioxide (Trisenox)
- Bortezomib (Velcade)
- Brentuximab Vedotin(Adcetris)
- Cetuximab (Erbitux)
- Cisplatin & Oxaliplatin
- Colchicine (extended use)
- Dapsone
- Didanosine (ddI, Videx)
- Dichloroacetate
- Disulfiram (Antabuse)
- Eribulin (Halaven)
- Fluoroquinolones
- Gold salts
- Ipilimumab (Yervoy)
- Ixabepilone (Ixempra)
- Leflunomide (Arava)
- Lenalidomide (Revlimid)
- Metronidazole/Misonidazole (extended use)
- Nitrofurantoin (Macrodantin, Furadantin, Macrobid)
- Nitrous oxide (inhalation abuse or Vitamin B12 deficiency)
- Nivolumab (Opdivo)
- Pembrolizumab (Keytruda)
- Perhexiline (not used in U.S.)
- Pomalidomide (Pomalyst)
- Pyridoxine (Although megadoses [10 times or more the RDA] of Vitamin B6 may be harmful, high intakes of vitamin B6 from food sources have not been reported to cause adverse effects.) NIH Fact Sheet
- Stavudine (d4T, Zerit)
- Suramin
- Thalidomide
- Zalcitabine (ddC, Hivid)
This is a list of the most common neurotoxic drugs for CMT, however, it may not include every drug with neurotoxic effects. Please talk with your doctor before starting or changing a medication.
UNCERTAIN OR MINOR RISK
- 5-Fluoracil
- Adriamycin
- Almitrine (not in U.S.)
- Chloroquine
- Cytarabine (high dose)
- Ethambutol
- Etoposide (VP-16)
- Gemcitabine
- Griseofulvin
- Hexamethylmelamine
- Hydralazine
- Ifosphamide
- Infliximab
- Isoniazid (INH)
- Lansoprazole (Prevacid)
- Mefloquine
- Omeprazole (Prilosec)
- Penicillamine
- Phenytoin (Dilantin)
- Podophyllin resin
- Sertraline (Zoloft)
- Statins
- Tacrolimus (FK506, ProGraf)
- Zimeldine (not in U.S.)
- a-Interferon
NEGLIGIBLE OR DOUBTFUL RISK
- Allopurinol
- Amitriptyline
- Chloramphenicol
- Chlorprothixene
- Cimetidine
- Clioquinil
- Clofibrate
- Cyclosporin A
- Enalapril
- Gluthethimide
- Lithium
- Phenelzine
- Propafenone
- Sulfonamides
- Sulphasalzine
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