DEFINITE HIGH RISK (INCLUDING ASYMPTOMATIC CMT)

 

  • Vinca alkaloids (Vincristine)
  • Taxols (paclitaxel, docetaxel, cabazitaxel)

 

MODERATE TO SIGNIFICANT RISK

 

  • Amiodarone (Cordarone)
  • Arsenic Trioxide (Trisenox)
  • Bortezomib (Velcade)
  • Brentuximab Vedotin(Adcetris)
  • Cetuximab (Erbitux)
  • Cisplatin & Oxaliplatin
  • Colchicine (extended use)
  • Dapsone
  • Didanosine (ddI, Videx)
  • Dichloroacetate
  • Disulfiram (Antabuse)
  • Eribulin (Halaven)
  • Fluoroquinolones
  • Gold salts
  • Ipilimumab (Yervoy)
  • Ixabepilone (Ixempra)
  • Leflunomide (Arava)
  • Lenalidomide (Revlimid)
  • Metronidazole/Misonidazole (extended use)
  • Nitrofurantoin (Macrodantin, Furadantin, Macrobid)
  • Nitrous oxide (inhalation abuse or Vitamin B12 deficiency)
  • Nivolumab (Opdivo)
  • Pembrolizumab (Keytruda)
  • Perhexiline (not used in U.S.)
  • Pomalidomide (Pomalyst)
  • Pyridoxine (Although megadoses [10 times or more the RDA] of Vitamin B6 may be harmful, high intakes of vitamin B6 from food sources have not been reported to cause adverse effects.) NIH Fact Sheet
  • Stavudine (d4T, Zerit)
  • Suramin
  • Thalidomide
  • Zalcitabine (ddC, Hivid)

This is a list of the most common neurotoxic drugs for CMT, however, it may not include every drug with neurotoxic effects. Please talk with your doctor before starting or changing a medication.  

UNCERTAIN OR MINOR RISK

  • 5-Fluoracil
  • Adriamycin
  • Almitrine (not in U.S.)
  • Chloroquine
  • Cytarabine (high dose)
  • Ethambutol
  • Etoposide (VP-16)
  • Gemcitabine
  • Griseofulvin
  • Hexamethylmelamine
  • Hydralazine
  • Ifosphamide
  • Infliximab
  • Isoniazid (INH)
  • Lansoprazole (Prevacid)
  • Mefloquine
  • Omeprazole (Prilosec)
  • Penicillamine
  • Phenytoin (Dilantin)
  • Podophyllin resin
  • Sertraline (Zoloft)
  • Statins
  • Tacrolimus (FK506, ProGraf)
  • Zimeldine (not in U.S.)
  • a-Interferon

NEGLIGIBLE OR DOUBTFUL RISK

  • Allopurinol
  • Amitriptyline
  • Chloramphenicol
  • Chlorprothixene
  • Cimetidine
  • Clioquinil
  • Clofibrate
  • Cyclosporin A
  • Enalapril
  • Gluthethimide
  • Lithium
  • Phenelzine
  • Propafenone
  • Sulfonamides
  • Sulphasalzine

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