DEFINITE HIGH RISK (INCLUDING ASYMPTOMATIC CMT)
- Vinca alkaloids (Vincristine)
- Taxols (paclitaxel, docetaxel, cabazitaxel)
MODERATE TO SIGNIFICANT RISK
- Amiodarone (Cordarone)
- Arsenic Trioxide (Trisenox/Cephalon)
- Auranofin (Ridaura/Prometheus)
- Aurothioglucose (Solganal/Schering)
- Bortezomib (Velcade)
- Brentuximab Vedotin (Adcetris)
- Cetuximab (Erbitux)
- Ciprofloxacin
- Cisplatin
- Colchicine (extended-use risk)
- Dapsone
- Didanosine (ddI, Videx)
- Dichloroacetate
- Disulfiram (Antabuse)
- Enoxacin (Penetrex)
- Eribulin (Halaven)
- Fluoroquinolones
- Gatifloxacin
- Gold salts
- Gold Sodium (Aurolate/Taylor)
- Ipilimumab (Yervoy)
- Ixabepilone (Ixempra)
- Leflunomide (Arava)
- Lenalidomide (Revlimid)
- Levofloxacin (Levaquin)
- Metronidazole/Misonidazole (extended-use risk)
- Misonidazole (extended-use risk)
- Moxifloxacin (Avelox)
- Nitrofurantoin (Macrodantin, Furadantin, Macrobid)
- Nitrous oxide (inhalation abuse or Vitamin B12 deficiency)
- Nivolumab (Opdivo)
- Norfloxacin (Noroxin)
- Pembrolizumab (Keytruda)
- Perhexiline (not used in U.S.)
- Pomalidomide (Pomalyst)
- Pyridoxine (risk with mega-dose)
- Sparfloxacin (Zagam)
- Stavudine (d4T, Zerit)
- Suramin
- Thalidomide (Celegene)
- Trovafloxacin/Alatrofloxacin (Trovan)
- Zalcitabine (ddC, Hivid)
UNCERTAIN OR MINOR RISK
- 5-Fluoracil
- Adriamycin
- Almitrine (not in U.S.)
- Chloroquine
- Cytarabine (high dose)
- Ethambutol
- Etoposide (VP-16)
- Fluvastatin (Lescol/Reliant)
- Gemcitabine
- Griseofulvin
- Hexamethylmelamine (Altretamine/Hexalen)
- Hydralazine
- Ifosphamide
- Infliximab
- Isoniazid (INH)
- Lansoprazole (Prevacid)
- Mefloquine
- Omeprazole (Prilosec)
- Phenytoin (Dilantin)
- Podophyllin resin
- Pravastatin (Pravachol)
- Rosuvastatin (Crestor/AstraZeneca)
- Sertraline (Zoloft)
- Simvastatin (Zocor)
- Statins
- Tacrolimus (FK506, ProGraf)
- Zimeldine (not in U.S.)
- a-Interferon
NEGLIGIBLE OR DOUBTFUL RISK
- Allopurinol
- Amitriptyline
- Chloramphenicol
- Chlorprothixene
- Cimetidine
- Clioquinil
- Clofibrate
- Cyclosporin A
- Enalapril
- Gluthethimide
- Lithium
- Phenelzine
- Propafenone
- Sulfonamides
- Sulphasalzine
This is a list of the most common neurotoxic drugs for CMT, however, it may not include every drug with neurotoxic effects. Please talk with your doctor before starting or changing a medication.
CITATIONS
Cavaletti G, Forsey K, Alberti P. Toxic medications in Charcot-Marie-Tooth patients: A systematic review. J Peripher Nerv Syst. 2023 Sep;28(3):295-307. doi: 10.1111/jns.12566. Epub 2023 Jun 5. PMID: 37249082.
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