Definite High Rick (Including Asyptomatic CMT)

• Vinca sulfate (Vincristine)
• Taxane (paclitaxel, docetaxel, cabazitaxel)

Moderate To Significant Risk

• Amiodarone (Cordarone)
• Arsenic Trioxide (Trisenox)
• Auranofin (Ridaura)
• Aurothioglucose (Solganal)
• Bortezomib (Velcade)
• Brentuximab Vedotin (Adcetris)
• Cetuximab (Erbitux)
• Ciprofloxacin
• Cisplatin
• Colchicine (extended-use risk)
• Dapsone
• Didanosine (ddI, Videx)
• Dichloroacetate (in clinical trials)
• Disulfiram (Antabuse)
• Enoxacin (Penetrex)
• Eribulin (Halaven)
• Fluoroquinolones
• Gatifloxacin
• Gold salts
• Gold Sodium (Aurolate/Taylor)
• Ipilimumab (Yervoy)
• Ixabepilone (Ixempra)
• Leflunomide (Arava)
• Lenalidomide (Revlimid)
• Levofloxacin (Levaquin)
• Metronidazole (Flagyl) (extended-use risk)
• Misonidazole (extended-use risk)
• Moxifloxacin (Avelox)
• Nitrofurantoin (Macrodantin, Furadantin, Macrobid)
• Nitrous oxide (inhalation abuse or Vitamin B12 deficiency)
• Nivolumab (Opdivo)
• Norfloxacin (Noroxin)
• Oxaliplatin (Eloxatin)
• Ofloxacin (Floxin)
• Pembrolizumab (Keytruda)
• Perhexiline (Pexsig) (not used in the U.S.)
• Pomalidomide (Pomalyst)
• Pyridoxine (Vitelle Nestrex) (risk with mega-dose)
• Sparfloxacin (Zagam)
• Stavudine (d4T, Zerit)
• Suramin
• Thalidomide (Celegene)
• Trovafloxacin/Alatrofloxacin (Trovan)
• Zalcitabine (ddC, Hivid)

Uncertain or Minor Risk

• 5-Fluoracil
• Adriamycin
• Almitrine (not in the U.S.)
• Atorvastatin (Lipitor)
• Chloroquine
• Cytarabine (high dose)
• Ethambutol
• Etoposide (VP-16)
• Fluvastatin (Lescol)
• Gemcitabine (Gemzar)
• Griseofulvin
• Hexamethylmelamine (Altretamine/Hexalen)
• Hydralazine
• Ifosphamide (Ifex)
• Infliximab (Remicade)
• Isoniazid (INH)
• Lansoprazole (Prevacid)
• Lovastatin
• Mefloquine (Lariam)
• Omeprazole
• Phenytoin
• Podophyllin resin (Prodocon-25) (high exposure or unintended route)
• Pravastatin
• Rosuvastatin (Crestor)
• Sertraline (Zoloft)
• Simvastatin (Zocor)
• Statins
• Tacrolimus (FK506, ProGraf)
• Zimeldine (withdrawn from the market and not in the U.S.)
• a-Interferon

Negligible or Doubtful Risk

• Allopurinol
• Amitriptyline (Elavil)
• Chloramphenicol
• Chlorprothixene (Taractan)
• Cimetidine
• Clioquinol
• Clofibrate (Atromid)
• Cyclosporin A (Sandimmune)
• Enalapril
• Gluthethimide
• Lithium
• Phenelzine (Nardil)
• Propafenone
• Sulfonamide (sulfacetamide, sulfabenzamide, sulfadiazine, sulfasalazine, sulfathiazole, sulfamethoxazole, sulfisoxazole)

Citations: Cavaletti G, Forsey K, Alberti P. Toxic medications in Charcot-Marie-Tooth patients: A systematic review. J Peripher Nerv Syst. 2023 Sep;28(3):295-307. doi: 10.1111/jns.12566. Epub 2023 Jun 5. PMID: 37249082.