DEFINITE HIGH RISK (INCLUDING ASYMPTOMATIC CMT)

 

  • Vinca sulfate (Vincristine) 
  • Taxane (paclitaxel, docetaxel, cabazitaxel)

 

MODERATE TO SIGNIFICANT RISK

 

  • Amiodarone (Cordarone) 
  • Arsenic Trioxide (Trisenox) 
  • Auranofin (Ridaura) 
  • Aurothioglucose (Solganal) 
  • Bortezomib (Velcade) 
  • Brentuximab Vedotin (Adcetris) 
  • Cetuximab (Erbitux) 
  • Ciprofloxacin 
  • Cisplatin 
  • Colchicine (extended-use risk) 
  • Dapsone 
  • Didanosine (ddI, Videx) 
  • Dichloroacetate (in clinical trials) 
  • Disulfiram (Antabuse) 
  • Enoxacin (Penetrex) 
  • Eribulin (Halaven) 
  • Fluoroquinolones 
  • Gatifloxacin 
  • Gold salts 
  • Gold Sodium (Aurolate/Taylor) 
  • Ipilimumab (Yervoy) 
  • Ixabepilone (Ixempra) 
  • Leflunomide (Arava) 
  • Lenalidomide (Revlimid) 
  • Levofloxacin (Levaquin) 
  • Metronidazole (Flagyl) (extended-use risk) 
  • Misonidazole (extended-use risk) 
  • Moxifloxacin (Avelox) 
  • Nitrofurantoin (Macrodantin, Furadantin, Macrobid) 
  • Nitrous oxide (inhalation abuse or Vitamin B12 deficiency) 
  • Nivolumab (Opdivo) 
  • Norfloxacin (Noroxin) 
  • Oxaliplatin (Eloxatin) 
  • Ofloxacin (Floxin) 
  • Pembrolizumab (Keytruda) 
  • Perhexiline (Pexsig) (not used in the U.S.) 
  • Pomalidomide (Pomalyst) 
  • Pyridoxine (Vitelle Nestrex) (risk with mega-dose)  
  • Sparfloxacin (Zagam) 
  • Stavudine (d4T, Zerit) 
  • Suramin 
  • Thalidomide (Celegene) 
  • Trovafloxacin/Alatrofloxacin (Trovan) 
  • Zalcitabine (ddC, Hivid)

UNCERTAIN OR MINOR RISK

 

  • 5-Fluoracil  
  • Adriamycin 
  • Almitrine (not in the U.S.) 
  • Atorvastatin (Lipitor) 
  • Chloroquine 
  • Cytarabine (high dose) 
  • Ethambutol 
  • Etoposide (VP-16) 
  • Fluvastatin (Lescol) 
  • Gemcitabine (Gemzar) 
  • Griseofulvin 
  • Hexamethylmelamine (Altretamine/Hexalen) 
  • Hydralazine 
  • Ifosphamide (Ifex) 
  • Infliximab (Remicade) 
  • Isoniazid (INH) 
  • Lansoprazole (Prevacid) 
  • Lovastatin 
  • Mefloquine (Lariam) 
  • Omeprazole 
  • Phenytoin 
  • Podophyllin resin (Prodocon-25) (high exposure or unintended route) 
  • Pravastatin 
  • Rosuvastatin (Crestor) 
  • Sertraline (Zoloft) 
  • Simvastatin (Zocor) 
  • Statins 
  • Tacrolimus (FK506, ProGraf) 
  • Zimeldine (withdrawn from the market and not in the U.S.) 
  • a-Interferon

    NEGLIGIBLE OR DOUBTFUL RISK

      • Allopurinol 
      • Amitriptyline (Elavil) 
      • Chloramphenicol 
      • Chlorprothixene (Taractan) 
      • Cimetidine 
      • Clioquinol 
      • Clofibrate (Atromid) 
      • Cyclosporin A (Sandimmune) 
      • Enalapril 
      • Gluthethimide  
      • Lithium 
      • Phenelzine (Nardil) 
      • Propafenone 
      • Sulfonamide (sulfacetamide, sulfabenzamide, sulfadiazine, sulfasalazine, sulfathiazole, sulfamethoxazole, sulfisoxazole) 

      This is a list of the most common neurotoxic drugs for CMT, however, it may not include every drug with neurotoxic effects. Please talk with your doctor before starting or changing a medication.

      CITATIONS

      Cavaletti G, Forsey K, Alberti P. Toxic medications in Charcot-Marie-Tooth patients: A systematic review. J Peripher Nerv Syst. 2023 Sep;28(3):295-307. doi: 10.1111/jns.12566. Epub 2023 Jun 5. PMID: 37249082.

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